All kickoff times are Pacific Time. Preseason record 1–2. Arizona defeated Los Angeles 26–14 on Sept. 13. Weeks 17 and 18 remain TBD.
| Week | Date | Opponent | Home/Away | Pacific | Result / TV |
|---|---|---|---|---|---|
| Pre 1 | Aug 13 | Houston Texans | Away | 5:00 PM | W 27–7 |
| Pre 2 | Aug 20 | San Francisco 49ers | Home | 7:00 PM | L 17–41 |
| Pre 3 | Aug 27 | Los Angeles Rams | Home | 7:00 PM | L 18–20 |
| 1 | Sep 13 | Arizona Cardinals | Home | 1:25 PM | L 14–26 |
| 2 | Sep 20 | Las Vegas Raiders | Home | 1:05 PM | CBS |
| 3 | Sep 27 | Buffalo Bills | Away | 10:00 AM | FOX |
| 4 | Oct 4 | Seattle Seahawks | Away | 1:25 PM | CBS |
| 5 | Oct 11 | Denver Broncos | Home | 1:05 PM | CBS |
| 6 | Oct 18 | Kansas City Chiefs | Away | 1:25 PM | CBS |
| 7 | Oct 25 | BYE | — | — | — |
| 8 | Nov 1 | Los Angeles Rams | Away | 1:05 PM | FOX |
| 9 | Nov 8 | Houston Texans | Home | 1:05 PM | CBS |
| 10 | Nov 16 | Baltimore Ravens | Away | 5:15 PM | ESPN |
| 11 | Nov 22 | New York Jets | Home | 1:05 PM | FOX |
| 12 | Nov 29 | New England Patriots | Home | 5:20 PM | NBC |
| 13 | Dec 6 | Tampa Bay Buccaneers | Away | 10:00 AM | CBS |
| 14 | Dec 13 | Las Vegas Raiders | Away | 1:05 PM | CBS |
| 15 | Dec 17 | San Francisco 49ers | Home | 5:15 PM | Prime Video |
| 16 | Dec 27 | Miami Dolphins | Away | 10:00 AM | FOX |
| 17 | TBD | Kansas City Chiefs | Home | TBD | TBD |
| 18 | TBD | Denver Broncos | Away | TBD | TBD |